Scientific programme

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Thursday, 18 May

13:00-20:00   Registration
17:00-17:30   Welcome coffee
17:30-20:30  

Opening ceremony

  • Greeting of guests
  • For HAE Patients’ Award Prize-giving ceremony

Laudation of Bruce Zuraw by Anthony Castaldo

  • Let the treatment fit the disease
    Bruce Zuraw
    „For HAE Patients” Award

Opening lectures I
/Chairs: F. Marceau, M. Riedl/

  • C1 Inhibitor – Where we came from to where we are going
    Alvin Schmaier

Friday, 19 May

08:15-09:45  

Opening lectures II
/Chairs: E. Aygören. B. Ritchie/

  • Angioedema and idiopathic systemic capillary leak syndrome
    Marco Cicardi
  • Angioedema- Histamine or Bradykinin?
    Avner Reshef
09:45-10:15   Coffee break
10:15-12:15  

Scientific lectures

The exploration of molecular mechanisms and advances in diagnosis – dig deep to uncover the truth
/Chairs: C. Drouet, P. Gál, P. Späth/

  • Bradykinin displays a biased agonism profile in B2 receptor mutants identified in patients with Hereditary Angioedema
    Rafael Filippelli-Silva

  • Design of fusion proteins that bind B1 and B2 receptors for bradykinin: progress toward diagnostic tools
    Xavier Charest-Morin

  • Comparing pathways of kinin formation in human whole blood: generating endogenous agonists of the bradykinin B2 and B1 receptors
    François Marceau

  • A novel potential triggering factor of HAE attacks:
    complement MASP-1 increases endothelial cell permeability
    Márta L. Debreczeni

  • Modeling the activation and inhibition by C1 inhibitor of lectin pathway proteases
    József Dobó

  • Algorithm to distinguish histamine and bradykinin-induced angioedema in Emergency Department
    Jacques Hébert

  • Bradykinin angioedema solution for biological diagnostic
    Delphine Charignon

  • Assay for functional C1 inhibitor deficiency: An ELISA that improves upon the chromogenic method
    Kusumam Joseph
12:15-13:45   Lunch break
13:45-14:30  

Scientific lectures

The events of an angioedema episode – a tour into hell and back
/Chairs: I. Martinez-Saguer, A. Zanichelli/

  • Emerging role for phospholipase enzymes in Hereditary Angioedema with C1-INH Deficiency
    Stefania Loffredo

  • An observation of contact system activation in the early angioedema suggests a systemic process prior to a local process
    Arije Ghannam

  • Novel high-resolution follow-up of the coagulation and fibrinolytic parameters in a single angioedematous attack of a C1-INH-HAE patient
    Nóra Veszeli

14:30-16:00  

Poster session I. & Coffee break

MINGLING WITH THE AUTHORS – SCIENCE IN THE SHOP-WINDOW I.
/Chairs: T. Bowen, H. Longhurst/

P-01  
  • SERPING1 gene typing in the era of Next-Generation Sequencing (NGS)
    Gedeon Loules
P-02  
  • Hereditary angioedema: Report from the Czech registry
    Roman Hakl

P-03  
  • Radiation as a trigger of attacks in a misdiagnosed patient with hereditary angioedema and Hodgkin’s disease
    Anastasios E. Germenis

P-04  
  • The KLKB1-Ser143Asn polymorphism: A new genetic biomarker predicting the age of disease onset in patients with hereditary angioedema due to C1-INH deficiency (C1-INH-HAE)
    Panagiota Gianni, Maria Zamanakou

P-05  
  • Acquired Angioedema due to C1INH deficiency. Description of 12 cases and screening for free and complexed anti-C1INH autoantibodies
    Albert López-Lera
P-06  
  • Role of Vascular Permeability Factors in patients with Hereditary Angioedema with C1 Inhibitor Deficiency
    Anne Lisa Ferrara
P-07  
  • Expression of bradykinin B1 and B2 receptors on lymphocytes and monocytes during the remission and attack in patients with Hereditary angioedema (HAE)
    Wojciech Dyga
P-08  
  • Genetic variants in SERPING1 and F12 genes in Polish patients with hereditary angioedema type I & II
    Teofila Książek

 P-09  
  • Development of a set of sensitive assays for measuring enzyme/c1-inhibitor complexes
    Anna Koncz

P-10  
  • Results from an interim analysis of a Ruconest treatment registry
    in Europe
    Roman Hakl

P-11  
  • The challenging management of idiopathic systemic capillary leak syndrome: survey from an Italian case series
    Maddalena A. Wu

P-12  
  • Complex interplay between autonomic and contact/complement systems underlying attacks of hereditary angioedema due to C1 inhibitor deficiency
    Maddalena A. Wu

P-13  
  • Early versus late administration of icatibant in patients with hereditary angioedema
    Irmgard Andresen

P-14   
  • Treatment administrated in attacks in hereditary angioedema during pregnancy and breastfeeding
    Marta Sánchez-Jareño
P-15  
  • Late onset of angioedema  attacks due to C1 inhibitor deficiency  – a diagnostic challenge
    Marcin Stobiecki
P-16  
  • Hereditary Angioedema Nationwide Genetic Study in Belarus
    Irina Guryanova

P-17  
  • Off-label subcutaneous use of 1500 IE C1-INH for prophylaxis in HAE? A case report.
    Melanie Nordmann-Kleiner
P-18  
  • The importance of C1q in diagnosis of acquired angioedema (AAE)
    Susanne Trainotti
P-19  
  • Hereditary Angioedema in Ukraine: A National Survey
    Liudmyla Zabrodska 

P-20  
  • Development of a sensitive assay for measuring C1-inhibitor protein
    Dominik Gulyás

Saturday, 20 May

08:30-10:00  

Opening lectures III
/Chairs: K. Bork, C. Katelaris/

  • Emergent nations of Eastern Europe and Hereditary Angioedema
    Dumitru Moldovan

Scientific lectures

A new identity for C1-INH therapy – a facelift for the better

  • Population pharmacokinetics of subcutaneous versus intravenous C1-INH concentrate for the prevention of HAE attacks
    Bruce Zuraw

  • Pharmacodynamic effects of subcutaneous C1-INH for the prevention of HAE attacks
    Marco Cicardi

  • Safety and efficacy of a C1 inhibitor for the prevention of hereditary angioedema attacks in children: interim results of a Phase 3 study
    Emel Aygören-Pürsün

10:00-10:30   Coffee break
10:30-12:15   Scientific lectures

The diversity of inhibitory therapies and the multitude of genes – hunters and their games
/Chairs: L. Bouillet, A. Grumach, M. Magerl/

  • BCX7353, a Once-Daily Oral Kallikrein Inhibitor, is Effective and Safe in the Prophylaxis of Acute Attacks in Patients with Hereditary Angioedema: Results from the First Interim Analysis of the APeX-1 Study
    Emel Aygören-Pürsün

  • A Phase 3 open-label extension study of the efficacy and safety of lanadelumab for the prevention of angioedema attacks in patients with hereditary angioedema: trial design
    Marc A. Riedl

  • Safety study of ATN-249, a new oral kallikrein inhibitor for hereditary angioedema
    Ira Kalfus

  • FXIIa-mediated kallikrein activity discriminates between HAE and normal plasma samples and is a pharmacodynamic marker for CSL312
    Anthony Roberts

  • Putative role of KLKB1 gene on HAE pathophysiology
    Renan P. Martin

  • Genotyping unknown hereditary angioedema (U-HAE) and idiopathic non-histaminergic acquired angioedema (InH-AAE): Preliminary evidence of pathogenic variants
    Maria Zamanakou

  • Hereditary Angioedema With Normal C1 Inhibitor: a cohort of Italian Patients
    Maria Bova

12:15-13:45   Lunch break
13:45-15:00  

Round table discussion

Genetics of Angioedema: A Precision Medicine promise
/Moderators: N. Brown, A. Germenis/ 

  • Molecular analysis of SERPING1 gene: to whom, when and how?
    Margarita López-Trascasa

  • Pharmacogenetics of angiotensin-converting enzyme (ACE)
    inhibitor-associated angioedema
    Nancy J. Brown

  • Genotyping C1-INH deficiency patients: Methods, pitfalls and biases
    Anastasios E. Germenis

15:00-17:00  

Poster session II & Coffee break

MINGLING WITH THE AUTHORS – SCIENCE IN THE SHOP-WINDOW II.
/Chairs: J. Björkander, T. Craig, E. Hack/

P-21  
  • Hereditary Angioedema in a Brazilian cohort: delay in diagnosis
    Solange O.R. Valle

P-22  
  • An investigation into the importance of body mass index in case of patients with hereditary angioedema caused by C1-inhibitor deficiency
    Tamás Szilágyi

P-23  
  • The clinical appearance of idiopathic nonhistaminergic acquired angioedema and its comparison to other hereditary angioedema forms
    Noémi Andrási

P-24  
  • Home treatment with conestat alfa in attacks of hereditary angioedema due to C1-inhibitor deficiency
    Nóra Veszeli

P-25  
  • Canadian physician survey on the medical management of hereditary angioedema
    Lisa Fu

P-26  
  • Ambiguous symptoms of hereditary angioedema may delay diagnosis of concomitant diseases: two case reports
    Inmaculada Martinez Saguer

P-27  
  • First kinetic follow-up of symptoms and complement parameters during a hereditary angioedema attack
    Nóra Veszeli

P-28  
  • Hereditary Angioedema in Mexican paediatric population
    Melissa I. Espinosa

P-29  
  • Management of Hereditary Angioedema in Slovak Republic – National Survey Results
    Milos Jesenak

P-30  
  • Quality of life in 41 patients with hereditary angioedema: first report from Iranian National Registry of Hereditary Angioedema
    Maryam Ayazi
P-31  
  • Hereditary angioedema in Bulgaria: clinical and therapeutic characteristics
    Anna Valerieva
P-32  
  • A global multicenter registry of patients with different forms of angioedema without urticaria
    Francesca Perego

P-33  
  • Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey
    Andrea Zanichelli

P-34  
  • A Survey of Hereditary Angioedema in Israel
    Iris Leibovich-Nassi
P-35  
  • Delayed diagnosis of hereditary angioedema in an adult patient.
    A case report
    Erika J. Sifuentes
P-36  
  • Emergency call number for isolated angioedema:
    an 4 month experience in France
    Isabelle Boccon-Gibod

P-37  
  • Hereditary Angioedema: analysis of 287 attacks treated with Berinert® in the French Cohort COBRA
    Laurence Bouillet

P-38  
  • Management of hereditary angioedema: C1-inhibitor esterase and icatibant acetate self-administration for acute attacks
    Ana Rodríguez

P-39  
  • Off-Label Intramuscular Administration of Conestat Alfa (rhC1inh) in HAE Patients: a Case Series
    Anna Valerieva

P-40  
  • Are we ready to propose a pharmacological approach for Hereditary Angioedema with normal C1 Inhibitor (HAEnlC1INH)?
    Anete S. Grumach
P-41  
  • New mutations in C1 inhibitor gene leading to hereditary angioedema
    Camila L. Veronez

P-42  
  • Clinical and analytical characteristics in children with hereditary angioedema due to C1-inhibitor deficiency
    Teresa Caballero

P-43  
  • Hereditary Angioedema Rapid Triage (HAE-RT) Tool: A Delphi Study
    Lisa Fu

P-44  
  • The effect of menopause on hereditary angioedema:
    a descriptive study about 48 postmenopausal French patients
    Aurore Billebeau

P-45  
  • Normal C1-INH Angioedema in Israel: Phenotyping and F12 Gene Sequencing
    Avner Reshef

P-46  
  • The Determinants of Hereditary Angioedema Disease Severity: Geno-Phenotypical Aspects
    Nihal Mete Gokmen

Late
poster
 
  • Hereditary angioedema, epilepsy and behavioral problems – Case presentation
    Katarina Stavrikj


Sunday, 21 May

08:30-10:15   

Opening lectures IV
/Chairs: H. Li, P. Nordenfelt/

  • Neutrophils and neutrophil signaling in inflammation
    Attila Mócsai

Scientific lectures

Accomplishments in clinical practice – a tribute to healthcare professionals

  • Management of patients with hereditary angioedema with normal C1 inhibitor and without F12 gene mutations
    Konrad Bork

  • Hereditary angioedema presenting in childhood is diagnosed in adulthood by non-pediatric physicians: findings from the Icatibant Outcome Survey
    Hilary Longhurst

  • How age, gender, and concomitant diseases influence the clinical course of hereditary angioedema
    Inmaculada Martinez Saguer

  • Comorbidities of patients with hereditary angioedema due to
    C1-inhibitor deficiency in Hungary
    Kinga V. Kőhalmi

10:15-10:45   Coffee break 
10:45-12:30  

Scientific lectures

Education&Nursing&QoL – novel hopes for a brighter future
/Chairs: H. Boysen, I. Leibovich-Nassi, W. Lumry/

  • Launching a new website for the HAE International Nursing Organization
    Iris Leibovich-Nassi

  • Patient’s educational therapeutic program “EDUCREAK”: fourth year assessment
    Isabelle Boccon-Gibod

  • Smartphone application to record data on attack and treatment patterns in patients with hereditary and acquired angioedema: findings from a Danish cohort
    Kristian B. Kreiberg

  • Hereditary Angioedema in Latin America: Are we improving?
    Anete S. Grumach

  • Can routine prophylactic subcutaneous C1-inhibitor [C1-INH(SC)] alleviate psychological and physical disabilities caused by HAE? Findings from the COMPACT study (NCT01912456)
    William R. Lumry

  • Health Related Quality of Life in adult patients with C1-INH-HAE
    Donatella Lamacchia

  • Study of Health-Related Quality of Life and disease activity in adults with HAE in Sweden
    Patrik Nordenfelt

12:30-13:00   Closing Ceremony
/Chairs: H. Farkas, L. Varga, B. Zuraw/
Grant for Young Investigators” prize-giving 
13:00-14:00   Lunch
14:00-   A two-year break…

 

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